Brintellix is an antidepressant that belongs to a group of drugs referred to as selective serotonin reuptake inhibitors (SSRIs). Brintellix affects brain chemicals that may become unbalanced. The drug is administered to treat major depressive disorder in adults. Brintellix contains the active substance vortioxetine. Major depression is a type of condition whereby patients have mood disturbances that interfere with daily activities. Some of the most common symptoms include feelings of worthlessness, sleep disturbances, feelings of anxiety, loss of interest in favorite activities and changes in weight.