Cortisporin is a combination drug that treats bacterial infections of the ear canal as well as providing relief from irritation, redness, and discomfort caused by certain ear problems. It is a prescription drug with anti-inflammatory and antibacterial properties. The Cortisporin solution consists of a combination of antibiotics and corticosteroid. It is made up of a combination of 2 antibiotics, which are neomycin sulfate and polymyxin B sulfate, and a cortisone-like medicine, hydrocortisone acetate. With the antibiotics, they work to slow the growth of bacteria or kill them while the corticosteroid helps reduce the inflammation that arises from the bacterial infection.