Xigduo XR is made up of metformin and dapagliflozin. Metformin and Dapagliflozin are oral diabetes drugs that assist in controlling blood sugar levels. Dapagliflozin does work by helping the kidneys eliminate glucose from your bloodstream. Metformin decreases glucose production in the liver and also makes your intestines take in less glucose. Xigduo XR is taken together with diet plus exercise to treat type 2 Diabetes. Dapagliflozin doesn't treat type 1 diabetes. Xigduo XR can also be used for functions not included in this medication guidebook.