Avandamet is a medicine used in the treatment of type 2 diabetes. The medicine is composed of two different diabetic drugs, metformin and rosiglitazone, which can only work in the presence of insulin. This is why the latter drug cannot be used in type 1 diabetes. Avandamet is used to stabilize sugar levels in the body and does this quite effectively. However, Avandamet is implicated in serious cardiovascular risks and this will need to be taken into consideration by your doctor.