Celebrex (celecoxib) is used to help reduce inflammation throughout the body. Celebrex is a nonsteroidal anti-inflammatory drug or NSAID. Celebrex treats rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and other conditions. Celebrex cannot cure these issues, but they can and do treat symptoms. It can also be used to manage pain, including severe menstrual side effects.