Combipatch is a drug composed of two female hormones: progestin (norethindrone) and estrogen (estradiol). Women use Combipatch to reduce symptoms of menopause (vaginal dryness, itching, burning or hot flashes). These symptoms occur if the body does not make enough estrogen. Progestin plays the role of reducing cancer risks to the uterus, which may result from using estrogen. However, some women who have previously removed their uterus do not need progestin, and, for this reason, should not use this drug.