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Galsulfase is used in treating a genetic condition called MPS VI or mucopolysaccharidosis. MPS VI is a metabolic disorder where the body lacks enzymes that are required for the breakdown of some proteins and sugars. These proteins and sugars can accumulate in the body and can lead to changes in facial features, heart problems, enlarged organs, breathing problems, changes in physical or mental abilities, hearing or vision loss, and abnormal structure. Below you will find the uses of Galsulfase.
- Mucopolysaccharidosis VI or Maroteaux-Lamy syndrome
Dosage of Galsulfase depends on the individual and the condition being treated. Galsulfase should be injected into a patient's vein through an IV, and a qualified medical expert should give the injection. Galsulfase injection should be given slowly and can take up to a period of 4 hours. Below you will find a typical dosage of Galsulfase.
- The recommended dosage for children and adults who are 5 years of age and older should be IV infusion 1 mg/kg once every week.
- A pretreatment with antihistamines with/without antipyretics should be considered 30-60 minutes before the start of the infusion
- Galsulfase can be diluted in sodium 0.9% chloride injection to attain 250mL. However, Galsulfase should be diluted in 100mL sodium chloride 0.9% injection for patients who are susceptible to fluid volume overload or patients weighing less than 20kg
Galsulfase Side Effects
Galsulfase can cause some side effects and should be used with caution to minimize the severity of these side effects. A patient can experience some side effects during Galsulfase infusion or 24 hours after infusion. Side effects that are mild or short-term do not need medical attention, but severe or persistent side effects do. Below you will find a list of side effects associated with Galsulfase. Note that not all possible side effects are listed. Common Galsulfase side effects
- Stomach pain
- Joint pain
- Ear pain
- Mild rash or itching
Serious Galsulfase side effects
- Eye redness
- Trouble breathing
- Flu symptoms
- Unusual weakness
- Pale skin
- Easy bruising or bleeding
- Rapid weight gain
- Snoring or sleep apnea
- Shortness of breath
Like any drug, Galsulfase may interact with other drugs and substances. Drug interactions can occur if a patient uses two drugs simultaneously. Drug interactions can affect how Galsulfase works or increase a patient's risk for serious side effects. Patients should ensure that they inform their doctors about all the medications in use. Patients should never stop, change or start the use of a new drug without informing the doctor. No drug interactions have been reported with Galsulfase. However, you should still discuss all medications being used with your doctor before beginning Galsulfase use.