Infliximab is an anti-inflammatory drug that reduces the damage done by a certain cytokine that is overactive in some patients. Infliximab blocks the actions of tumor necrosis factor alpha (TNF-alpha), which is responsible for systemic inflammation that leads to pain and disability. Infliximab is used to treat numerous disorders of which inflammation is the main culprit. This includes rheumatoid arthritis, Crohn's disease, ulcerative colitis and plaque psoriasis. Infliximab has often proven useful where other drugs have failed.