Nitroglycerin rectal, otherwise known as, is in the drug class of nitrates. This drug class is only used in order to treat mild or moderate to severe anal fissures. Anal fissures, or tears in the lining of the anus, can be extremely painful, and Rectiv will soothe that pain over time. Rectiv, or nitroglycerin rectal, may be administered exclusively rectally. This means that a doctor or other health care professional must administer the nitroglycerin rectal in a hospital or clinical setting, or the patient may administer nitroglycerin rectal at home. This may be more comfortable to the patient to administer Rectiv at home.