The drug Novasus is a combination drug that consists of 2 main ingredients. These are Chlorpheniramine and Hydrocodone. Chlorpheniramine is an antihistamine drug that acts against the natural chemical histamine found in the human body. Hydrocodone is a narcotic drug used as a cough suppressant. The combined medicine, Novasus is used to treat a number of conditions. Histamine sometimes causes watery eyes, sneezing, a runny nose and itching. It is a brand medication that consists of a number of generic drugs.