Oxaliplatin is a chemotherapy drug used to treat colon cancer and rectal cancer, among others. Oxaliplatin works to kill cancer cells. During this process, it is used together with leucovorin and fluorouracil, also anti-cancer drugs. It is administered intravenously. Like many other chemotherapy drugs, oxaliplatin often causes severe nausea and vomiting. Your doctor may prescribe you other drugs to help deal with these side effects.