Pioglitazone is a prescription drug from the class of thiazolidinedione (TZD) that is used together with a proper diet and an exercise program. This helps to control high blood sugar in patients with type 2 diabetes. Pioglitazone works by helping restore the proper response of your body to insulin, thus lowering your blood sugar. Controlling high blood sugar greatly helps preventing kidney damage, nerve problems, blindness, sexual function problems and loss of limbs. Proper control of diabetes also lessens the risk of stroke or heart attack. Pioglitazone can be used either alone or in combination with other anti-diabetic medications.