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Zoloft acts by increasing the activity of serotonin in the brain, which can relieve symptoms related to depression, anxiety, and traumatic experiences. It accomplishes this by inhibiting the reabsorption of serotonin, which allows the chemical to linger in the brain. Zoloft and other SSNRIs (selective serotonin reuptake inhibitors) are generally used for severe cases of depression and stress, and are not considered as effective when applied to milder forms of the disorders.
Below is a list of the uses for Zoloft.
- Obsessive-compulsive disorder
- Social Anxiety Disorder
- Panic Disorder
- Post-traumatic stress disorder
- Premenstrual dysphoric disorder
Zoloft dosage is dependent on the individual that it is being administered to. Zoloft should be administered once daily, either in the morning or evening. The following dosage is an average dose and could differ among individuals. Follow your medical professional's directions for best results.
Major Depressive Disorder and Obsessive-Compulsive Disorder
- Treatment should be administered at a dose of 50 mg once daily
Panic Disorder, Posttraumatic Stress Disorder and Social Anxiety Disorder
- Treatment should be initiated with a dose of 25 mg once daily. After one week, the dose should be increased to 50 mg once daily
Premenstrual Dysphoric Disorder
- Treatment should be initiated with a dose of 50 mg/day, either daily throughout the menstrual cycle or limited to the luteal phase of the menstrual cycle, depending on physician assessment
Dosage for Children and Adolescents:
- Zoloft treatment should be initiated with a dose of 25 mg once daily in children (ages ,12) and at a dose of 50 mg once daily in adolescents (ages 1,17).
Zoloft Side Effects
While taking Zoloft, individuals may experience different side effects. Note, not all side effects are listed here. If you experience any severe side effects, consult with your doctor immediately or seek medical attention.
Common side effects of Zoloft include:
- nausea, loss of appetite, diarrhea or indigestion
- change in sleep habits including increased sleepiness or insomnia
- increased sweating
- sexual problems including decreased libido and ejaculation failure
- tremor or shaking
- feeling tired or fatigued
If you experience any of the following side effects, notify your doctor immediately:
- Suicidal thoughts or actions
- new or worse depression
- new or worse anxiety or panic attacks
- feeling agitated, restless, angry or irritable
- agitation, hallucinations, coma or other changes in mental status
- coordination problems or muscle twitching
- racing heartbeat, high or low blood pressure
- sweating or fever
- nausea, vomiting, or diarrhea
- muscle rigidity
- abnormal bleeding
- Feeling anxious or trouble sleeping
Like any medication, Zoloft may be affected by other drugs and substances. In many cases Zoloft should not be combined with other medications unless approved by a physician. Consult your physician before taking any new medication even if it is an over the counter drug, vitamin, or herbal substance. Zoloft should not be taken with Monoamine Oxidase Inhibitor (MAOI) drugs, including linezolid and methylene blue. If you have recently been taking a MAOI, tell your doctor. Do not begin taking a MAOI within 2 weeks of discontinuing Zoloft treatment. Do not take Zoloft if you are allergic to sertraline or any of the other ingredients.
Below is a list of some of the drugs known to interact with Zoloft.
- CNS-active drugs